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. 2006 Mar 8;26(10):2767–2776. doi: 10.1523/JNEUROSCI.5054-05.2006

Figure 7.

Figure 7.

Ketamine application to control slices mimics the anatomical profile of disrupted gamma rhythms seen in LPA1−/− slices. A, Example traces show 0.5 s of field potential activity in superficial (layer II) and deep (layer IV/V) laminas in the presence and absence of ketamine (20 μm). Calibration: 50 μV, 100 ms. Pooled power spectra (n = 7) illustrate the selective reduction in gamma frequency oscillations in superficial entorhinal cortex. B, Example traces show 0.5 s of field potential activity in hippocampal area CA3 in the presence and absence of ketamine (20 μm). Calibration: 50 μV, 100 ms. Pooled power spectra (n = 7) show lack of effect of ketamine on hippocampal gamma rhythms. Control data are plotted as solid lines; data gathered in the presence of ketamine are plotted as dashed lines.