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. 2006 Mar 8;26(10):2673–2683. doi: 10.1523/JNEUROSCI.4689-05.2006

Figure 9.

Figure 9.

Miniature spontaneous excitatory currents in cortical astrocytes are mediated by AMPA and NMDA glutamate receptors. A, Representative whole-cell recordings in control and after application of NBQX (30 mm). The right panels represent generalized waveform of spontaneous currents (average of 50 events). The bottom graph shows probability density function of spontaneous currents in control (solid line) and in the presence of NBQX (dots). B, Representative whole-cell recordings from astrocytes in cortical slice in control and after application of d-AP-5 (30 μm). The right panel shows a generalized waveform of spontaneous currents (average of 50 events). The bottom graph shows probability density function of spontaneous currents in control (solid line) and in the presence of d-AP-5 (dots). All recordings were made at a holding potential of −80 mV in the presence of TTX (1 μm), picrotoxin (100 μm), and dl-TBOA (100 μm). Note the significant decrease in the amplitude of spontaneous current as well as leftward shift of amplitude distributions under action of glutamate receptor antagonists.