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. 2006 Mar 8;26(10):2830–2838. doi: 10.1523/JNEUROSCI.3344-05.2006

Figure 4.

Figure 4.

HDA-3 specifically rescues hda-3(tm1374) suppression of Htn-Q150 in ASH neurons. Degeneration is reduced from 27 ± 2% in rtIs11Htn-Q150 animals to 6 ± 6% in hda-3(tm1374); rtIs11(Htn-Q150) animals at day 7. Degeneration ranges from 14 to 63%, depending on the transgenic line (average, 45 ± 22%) in hda-3(tm1374); rtIs11(Htn-Q150); srb-6:hda-3 transgenic animals. As a control, a plasmid carrying the empty srb-6 promoter was injected along with transgenic markers. The empty promoter has no significant effect on polyQ toxicity (10 ± 3%). Overexpression of hda-3 in ASH using the srb-6 promoter increases degeneration from 24 ± 11 to 45 ± 13% (p = 0.03). ***p < 0.0005 compared with column 1 for each graph; ###p < 0.0005 when comparing hda-3;Htn-Q150; srb-6::hda3 with hda-3;Htn-Q150. At least three trials were conducted for each experiment to total n > 150. Error bars represent SD.