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. 2006 Mar 8;26(10):2830–2838. doi: 10.1523/JNEUROSCI.3344-05.2006

Figure 5.

Figure 5.

HDA-3 modulates Htn-Q150 toxicity via transcriptional regulation. Loss of hda-3 function suppresses the deleterious effects of loss of crh-1 function. ASH neuron degeneration is increased in crh-1;rtIs11[Htn-Q150] animals and decreased in hda-3(tm1374);rtIs11[Htn-Q150] animals compared with rtIs11[Htn-Q150]. ASH degeneration is suppressed in hda-3(tm1374);crh-1; rtIs11[Htn-Q150] animals and is not significantly different from degeneration levels in hda-3(tm1374);rtIs11[Htn-Q150] animals at day 7. Error bars represent SD. ***p < 0.0005 compared with column 1 of each graph. At least three trials were conducted for each determination to total n > 150.