Figure 6.

The slow oscillation is abolished by muscarinic agonism and enhanced by muscarinic antagonism during urethane anesthesia. A, Simultaneously recorded field signals from the HPC and nCTX showing a spontaneous state change. B, After intraperitoneal administration of 4 mg/kg oxotremorine, a continuously activated (theta and LVFA) state was elicited. C, Conversely, subsequent intraperitoneal administration of 50 mg/kg atropine sulfate (AtSO₄) elicited a continuous deactivated (SO) state. D, Spectra of spontaneous and pharmacologically induced states appeared highly similar in terms of peak frequencies (E) as well as peak power values (F) and statistical comparison verified that there was no significant difference. fiss, Fissure; TH, theta; Oxo, oxotremorine; Spon, spontaneous; Eser, eserine.