Figure 1.

Comparison of HAP1A with HAP1B. A, Different C-terminal sequences of rat HAP1A and HAP1B. The PKA phosphorylation site is indicated in gray. The htt binding region is indicated in the black box. B, Distribution of HAP1A and HAP1B in PC12 cells treated with NGF (50 ng/ml) for 3 d. HAP1A (top) is localized in neurite tips, whereas HAP1B (bottom) is predominantly in the cell body. PC12 cells were labeled by antibodies against the specific C-terminal sequences of HAP1A and HAP1B as underlined in A.