Figure 2.

Regenerative sprouting in wild-type and Nogo-A knock-out mice after spinal cord injury. In wild types, sprouts (thin arrows) are short (A, B). In knock-out mice (KO), sprouts elongate over ventral tissue bridges toward the caudal spinal cord in both strains (C, D). Many sprouts end at the scar in all of the animals (thick arrow). Scale bar, 68 μm. E, Quantification of regenerative sprouting of the transected main CST axons rostral to the lesion in wild-type (wt) and homozygous Nogo-A knock-out (KO) animals of the Sv129 and the BL/6 strain. Sprouting was assessed by two experienced observers using a 0–3 point scoring scale. *p < 0.02 (Mann–Whitney U test).