Figure 2.

Short-term synaptic plasticity was altered after chronic THC exposure (A). Pretreatment with SR141716A (SR; 3 mg/kg, i.p., 20 min before THC injection) prevented PPF reduction (B). Top, Purkinje cell EPSC PPF at intervals of 50, 100, 150, 200, and 250 ms after chronic vehicle (Veh) and chronic THC. Stimulus artifacts were suppressed for clarity. Bottom, PPF ratio values (mean ± SEM) plotted against paired-pulse intervals. Asterisks indicate significant differences (p < 0.01) from chronic vehicle.