Figure 6.

Terminal area and intervesicle distance at corticothalamic terminals were increased in the knock-out mice. A, Frequency distribution of RS terminal area in synapsin I and II knock-out (KO) compared with wild-type (WT) mice. Increased area, rather than reduction in number of vesicles, could explain the decreased vesicle density in the knock-out mice as illustrated schematically in the inset. In each pair of bars, the black one is for wild type, and the gray one is for knock-out. Bin width, 0.065 μm². B, Average intervesicle distances distance in RL and RS terminals in wild-type and knock-out mice. Deletion of synapsins led to increased distance between synaptic vesicles as illustrated in the inset. The error bars are SEM.