Figure 5.

HPC-1/syntaxin 1A KO mice exhibited normal spatial memory in the hidden platform test. Each mouse was handled for 3–5 d before training and subjected to the hidden platform test in a Morris water maze (WT, n = 9; HT, n = 7; KO, n = 19). Data represent mean ± SD. A, The average swim path length to reach the escape platform on each training day is shown. A similar decrease in swim path length to reach the platform during 5 d of training was observed for each genotype. There was no significant difference among genotypes. B, The average swim speed on each training day is shown. There were no significant differences among genotypes. C, After 5 d of training, each mouse underwent a probe test. The average percentage of time spent in each of the four quadrants of the pool is shown. There were no significant differences among genotypes. TG, Quadrant where the platform was located during training for the hidden platform test; OP, opposite; R, right; L, left.