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. 2006 May 24;26(21):5794–5799. doi: 10.1523/JNEUROSCI.0372-06.2006

Figure 3.

Figure 3.

In the hippocampus and somatosensory cortex, CB1 on glutamatergic neurons is necessary for the WIN-induced inhibition of glutamatergic transmission. A, In the CA1 region of the hippocampus, EPSPs are reduced to 49.6 ± 4.3% (n = 12) after application of WIN (5 μm) in CB1f/f mice but not in slices of CB1f/f;CaMKIIαCre mice (109.9 ± 4.2%; n = 12). B, AMPA-EPSC amplitudes are decreased by WIN only in CB1f/f mice (EPSCs of CB1f/f: 52.7 ± 11.1%, n = 6; EPSCs of CB1f/f;CaMKIIαCre: 96.9 ± 8.2%, n = 6). C, In the somatosensory cortex of layer II neurons, WIN reduces the AMPA-EPSC amplitude in CB1f/f mice to 49.7 ± 5.0% (n = 8), whereas in CB1f/f;CaMKIIαCre mice, WIN has no effect (105.4 ± 4.3%; n = 8). Representative traces are shown. Picro, Picrotoxin; CGP, CGP 35348.

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