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. 2006 May 17;26(20):5524–5533. doi: 10.1523/JNEUROSCI.3050-05.2006

Figure 3.

Figure 3.

Hippocampal DNA recombination is related to consolidation of context fear conditioning. A, Representative Southern blot showing NHEJ rD and rT products generated by hippocampal protein extracts. S, DNA substrate. Lane 1, Negative control (DNA end-joining results when using heat-denatured protein); lanes 2–5, DNA end-joining products generated by hippocampal protein extracts prepared from mice killed immediately, 10 min, 30 min, or 60 min after training; lane 6, empty, nothing loaded; lane 7, DNA end-joining products generated by hippocampal protein extracts prepared from naive mice. B, Bar graph showing the relative generation of rD NHEJ products by hippocampal (filled bars) and cortical (hatched bars) protein extracts. The hippocampal peaks of NHEJ activity at 10 and 60 min were statistically significant (***p < 0.0001 each). Error bars indicate SEM.