Table 1. Baseline hemodynamic and physical parameters.
WT | TLR4-/- | WT + MTS 510 | |
---|---|---|---|
n = 38 | n = 37 | n = 15 | |
baseline before preparation for CA/CPR | |||
body weight [g] | 20,67 [± 2,0] | 22,08 [± 3,1] | 20,44 [± 1,4] |
heart rate [1/min] | 244 [± 32] | 233 [± 23] | 241 [± 31] |
MAP [mm Hg] | 101 [± 11] | 90 [± 11] | 94 [± 8] |
body temperature [°C] | 36,0 [± 0,1] | 36,0 [± 0,1] | 36,0 [± 0,1] |
parameter of CA/CPR | |||
ROSC time [s] | 84 [± 25] | 77 [± 20] | 65 [± 22] |
ROSC rate | 100% | 100% | 100% |
Adrenalin (μg) | 15,0 [10 – 15] | 12,5 [10 – 15] | 12,5 [10 – 15] |
weaning (min) | 140 [± 12] | 137 [± 10] | 136 [± 8] |
1 hour after CA/CPR | |||
heart rate [1/min] | 429 [± 37] | 457 [± 26] | 440 [± 42] |
MAP [mm Hg] | 67 [± 8] | 63 [± 12] | 71 [± 10] |
body temperature [°C] | 36,4 [± 0,2] | 36,0 [± 0,3] | 36,2 [± 0,1] |
2 hours after CA/CPR | |||
heart rate [1/min] | 277 [± 27] | 301 [± 33] | 287 [± 27] |
MAP [mm Hg] | 60 [± 10] | 65 [± 15] | 64 [± 12] |
body temperature [°C] | 36,0 [± 0,2] | 36,0 [± 0,1] | 36,1 [± 0,2] |
observation period after CA/CPR | |||
body temperature | |||
4 h post CA/CPR [°C] | 35,4 [± 0,8] | 35,0 [± 0,9] | 35,7 [± 0,5] |
8 h post CA/CPR [°C] | 35,2 [± 1,0] | 34,8 [± 1,3] | 35,1 [± 1,2] |
12 h post CA/CPR [°C] | 35,8 [± 0,9] | 35,2 [± 0,8] | 35,2 [± 0,9] |
24 h post CA/CPR [°C] | 35,0 [± 1,2] | 35,4 [± 1,1] | 35,1 [± 1,4] |
adverse events | |||
seizures [n] | 4 | 5 | 2 |
paresis of hind limbs | |||
irreversible [n] | 5 | 4 | 1 |
reversible [n] | 1 | 2 | 1 |