Table 3.
Reduced dosage of GABAA receptor gene Rdl or GABA biosynthetic gene Gad1 suppresses kccDHS1 and some other BS mutations
| Genotype | % Bang sensitivity |
p value | |||
|---|---|---|---|---|---|
| Test | (n) | Control | (n) | ||
| kccDHS1; Rdl1/+ | 1 | (301) | 26 | (231) | 3.7 × 10−19 |
| bss1/+; Rdl1/+ | 53 | (146) | 78 | (137) | 1.0 × 10−5 |
| sdaiso7.8/+; Rdl1/+ | 1 | (144) | 2 | (80) | 1.9 × 10−9 |
| easPC20/+; Rdl1/+ | 0 | (104) | 0 | (94) | |
| kccDHS1; Gad1L352F/+ | 3 | (72) | 28 | (47) | 1.0 × 10−4 |
| bss1 f/+; Gad1L352F/+ | 19 | (145) | 53 | (110) | 1.9 × 10−7 |
| easPC20/+; Gad1L352F/+ | 0 | (85) | 0 | (49) | |
Genotypes for Rdl1/+ and Gad1L352F/+ test flies (labeled “Test”) are indicated; control siblings (labeled “Control”) carried the TM6B balancer chromosome rather than the Rdl1 null allele of Rdl. Results are highly significant (p < 0.001) for all BS genotypes listed, except eas/+. Rdl1/+ produced slight (4%) suppression of hemizygous bss (p = 0.06).