Figure 4.

Prolongation of EPC decay does not occur in ClC-1 chloride channel null mice that do not upregulate fetal-type AChRs. A, Superimposed EPCs from an active ClC endplate (black) and a ClC endplate in which synaptic activity was blocked for 8 d (gray). B, Mean EPC integral in active ClC endplates (black) and ClC endplates in which synaptic activity was blocked for 7–10 d (gray). There is no statistically significant difference in EPC integral after block of synaptic activity in ClC endplates (p = 0.17). n = 7 muscles for both active ClC endplates and ClC endplates in which nerve activity was blocked. Error bars represent the SEM.