Figure 2.

Expression of p48 or m44 restores normal recovery to flash responses. A, Families of responses to increasing flash strengths from representative wild-type, knock-out, and transgene-positive rods. Responses have been normalized by the maximal response amplitudes, which were (in pA) 11.4 (WT), 10.8 (Arr–/–), 17.0 (m44^Arr–/–), and 14.6 (p48^Arr–/–). Flash strengths ranged from (in photons/μm²) 20.4 to 2612 by factors of 4 (WT); 6.2 to 2621 by factors of 4 (m44^Arr–/–); 20.5 to 2621 by factors of 4 (p48^Arr–/–) and for Arr–/– were 8.9, 17.6, 24, 227, and 1154. B, Population mean single-photon responses from WT (n = 21), m44^Arr–/– (n = 13), and p48^Arr–/– (n = 11) rods. A representative scaled dim flash response from an Arr–/– rod is shown for comparison. Right panel is same traces as on the left, shown on an expanded timescale. Error bars represent SEM. In all panels, flashes (10 ms, 500 nm) were delivered at t = 0.