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. 2006 Jan 18;26(3):971–980. doi: 10.1523/JNEUROSCI.4423-05.2006

Figure 5.

Figure 5.

Effects of the EGF receptor inhibitor on the DHPG-induced JNK phosphorylation in cultured rat striatal neurons. A, The EGF ErbB1 receptor inhibitor AG1478 blocked the DHPG-induced JNK phosphorylation (n = 6). B, The ErbB2 receptor inhibitor AG825 did not affect the DHPG-induced JNK phosphorylation (n = 3). C, Effects of AG1478 or AG825 on the EGF- or PMA-induced JNK phosphorylation (n = 4). AG1478, but not AG825, blocked JNK phosphorylation induced by the recombinant human EGF. Both of the inhibitors had no effect on the PMA-stimulated JNK phosphorylation. Representative immunoblots are shown to the left of the quantified data of pJNK1. AG1478 or AG825 (0.1 μm) was incubated 15 min before and during a 10 min treatment with DHPG (100 μm), EGF (10 ng/ml), or PMA (1 μm). *p < 0.05 versus basal levels. +p < 0.05 versus DHPG (A) or EGF (C) alone.