Figure. 6.

Correlations between agonist response profiles and properties of mouse lamina II neurons. A, Membrane potentials of lamina II neurons plotted as a function of agonist response profile and genotype. DAMGO-responsive wild-type and GIRK3 knock-out lamina II neurons were relatively hyperpolarized compared with neurons of the same genotype with different agonist response profiles. Furthermore, DAMGO-responsive and baclofen-responsive GIRK1 knock-out and GIRK2 knock-out neurons were significantly depolarized compared with wild-type and GIRK3 knock-out groups. B, The apparent capacitance values of lamina II neurons plotted as a function of agonist response profile and genotype. The DAMGO-responsive lamina II neurons in all genotypes exhibited significantly greater apparent capacitance values than the baclofen-responsive neurons. *p < 0.05 and **p < 0.01 versus DAMGO (within-genotype group); ⁺p < 0.05 and ⁺⁺p < 0.01 versus wild type (within-agonist group). Error bars indicate SEM. w, Wild type; 1, GIRK1 knock-out; 2, GIRK2 knock-out; 3, GIRK3 knock-out.