Figure 5.

A–C, Chronic cold stress increases the proportion of NE axons dually labeled for NET and TH (large arrows). Electron microscopic images illustrate that immunogold-silver particles for NET are predominantly associated with the plasma membrane in these profiles. In C, the dually labeled profile forms a symmetric synapse (medium black arrow) onto a dendritic shaft (d), and gold–silver particles (small black arrows) are localized to the plasma membrane immediately surrounding the synaptic contact. Neither of these two observations was ever made in control rats. Scale bar, 0.48 μm.