Skip to main content
. 2006 Feb 1;26(5):1457–1464. doi: 10.1523/JNEUROSCI.3786-05.2006

Figure 1.

Figure 1.

a, K252a attenuates the Tat–RACK1 effect on voluntary ethanol intake in mice. Tat–RACK1 (4 mg/kg), Tat–RACK1 (4 mg/kg) plus K252a (25 μg/kg), or vehicle was administered at 3 P.M., and the amount of ethanol consumed overnight was recorded. Data are presented as mean ± SEM grams/kilogram of body weight. n = 12. *p < 0.01 compared with vehicle. b, c, Activation of the BDNF receptor TrkB regulates ethanol consumption. The Trk receptor inhibitor K252a (5 and 25 μg/kg) or vehicle was administered at 3 P.M., and the amount of ethanol consumed overnight was recorded. Data are presented as mean ± SEM grams/kilogram of body weight. b, Inhibition of the Trk receptor increases ethanol intake in BDNF+/+ mice. n = 12. *p < 0.05 compared with saline. c, K252a has no effect on ethanol intake in BDNF+/− mice (n = 9).