Figure 2.

DHT- and ERβ-selective ligands suppress the hormonal response to restraint stress. Wax pellets containing E2, DHT, 3β-diol, DPN, moxestrol (Mox), or PPT were implanted directly above the PVN, and the hormonal response to a 30 min restraint stress was measured. A, Corticosterone levels. B, ACTH levels in stressed animals after central treatment with DHT, the ERβ-selective compounds 3β-diol and DPN with E2, or the ERα-selective ligands moxestrol and PPT. The asterisk indicates groups that were significantly different from vehicle controls (p < 0.05). Each bar represents the mean ± SEM of six or seven animals.