Figure 5.

Effects of COMT Val108/158Met polymorphism on functional coupling of the prefrontal cortex and the hippocampus. A, A representative volume of interest from a single subject. Volumes of interest were spheres with a radius of 6 mm and contained up to 32 voxels. B, Compared with Val homozygous subjects, Met/Met carriers showed significantly stronger functional coupling between the left hippocampus and both the left and right prefrontal cortex. [x, y, z], Voxel coordinates in MNI reference space.