Table 2.
Putative Zif268-regulated proteasome genes and randomly selected genes used for the bioinformatic analysis
| Proteasome genes | ERE | Sp1 | NFκB | Randomly selected genes | ERE | Sp1 | NFκB |
|---|---|---|---|---|---|---|---|
| anapc1 | 2 | 2 | 0 | NM_001916.2 | 0 | 1 | 1 |
| cdc5-like | 2 | 5 | 3 | BRD4 | 0 | 4 | 2 |
| cop1 | 6 | 5 | 1 | C14orf15 | 0 | 3 | 2 |
| Herc3 | 3 | 2 | 2 | C20orf26 | 0 | 11 | 0 |
| mdm2 | 4 | 5 | 1 | DKFZp761G058 | 1 | 3 | 2 |
| Nedd4 | 2 | 5 | 1 | FLJ20343 | 2 | 1 | 1 |
| Nedd8-UB1 | 8 | 7 | 4 | HEG | 0 | 4 | 2 |
| psma5 | 1 | 8 | 1 | KIAA1958 | 4 | 5 | 0 |
| psmb8 | 5 | 4 | 1 | LIN7C | 1 | 2 | 1 |
| psmb9/Tap1 | 4 | 6 | 3 | LOC148003 | 0 | 1 | 1 |
| psmc4 | 2 | 13 | 2 | LOC388524 | 0 | 2 | 1 |
| psme1 | 3 | 1 | 0 | LOC388617 | 0 | 18 | 0 |
| psme2 | 8 | 14 | 2 | LOC392539 | 0 | 14 | 0 |
| Rhysin2 | 3 | 2 | 2 | LOC401352 | 2 | 3 | 2 |
| SAK | 3 | 0 | 0 | LOC402055 | 1 | 27 | 0 |
| SGK | 7 | 9 | 0 | MAC30 | 2 | 2 | 2 |
| sgt | 3 | 1 | 1 | PCDHA10 | 0 | 11 | 0 |
| Tap2 | 3 | 10 | 3 | RCN2 | 6 | 1 | 1 |
| tapasin | 7 | 11 | 3 | ZNF26 | 2 | 1 | 0 |
| ubc7 | 5 | 1 | 1 | ZNF530 | 1 | 1 | 1 |
| UBE2l6 | 2 | 6 | 2 | ||||
| ubiquilin | 5 | 4 | 2 | ||||
| ubiquitinD | 2 | 2 | 1 | ||||
| vhl | 4 | 3 | 1 |
The candidate Zif268-regulated proteasome genes were compared with a randomly selected set of genes (see Materials and Methods) for the number of potential EREs, Sp1 sites, and NFκB sites present in the upstream regions. For details of procedures, see Materials and Methods. The consensus sequences are as follows: ERE, TGCGTRGGCGK; Sp1, NGGGGGCGGGGYN; NFκB, SGGRNWTTCC. Note that bioinformatic predictions are not in themselves indicative of functional significance.