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. 2006 Feb 1;26(5):1579–1587. doi: 10.1523/JNEUROSCI.4132-05.2006

Figure 1.

Figure 1.

Acute and repeated cocaine elevate F-actin in the accumbens. a, Cocaine treatment regimens: Sa/Sa, repeated saline/acute saline; Sa/Coc, repeated saline/acute cocaine; Coc/Sa, repeated cocaine/acute saline; Coc/Coc, repeated cocaine/acute cocaine. b, Acute and repeated cocaine elevate F-actin and reduce G-actin without affecting total actin at 45 min after injection. c, The effect of acute cocaine is absent at 120 min after injection. d, Repeated cocaine reduces F-actin in the prefrontal cortex. e, Withdrawal from repeated amphetamine and morphine elevate F-actin in the accumbens. Data are shown as mean ± SEM, and the number of determinations is shown in each bar. Data were evaluated using a one-way (c, e) or two-way (acute × chronic; b, d) ANOVA: b, F-actin, interaction, F(1,20) = 6.19, p = 0.022; G-actin, interaction, F(1,25) = 5.31, p = 0.030; d, prefrontal cortex, chronic, F(1,17) = 7.90, p = 0.012; e, F(2,10) = 5.78, p = 0.022. *p < 0.05 compared with Sa/Sa (b) or between repeated saline and cocaine/amphetamine (Amph)/morphine (Morph) (d, e) using a Fisher's LSD post hoc comparison.