Cocaine alters ABPs that regulate actin polymerization. For treatment regimens, see
Figure 1a. Data are shown as
mean ± SEM, and the number of determinations is shown in each bar. The data
were evaluated using a two-way ANOVA: Mena, chronic,
F(1,24) = 8.09, p = 0.009; p-VASP,
chronic, F(1,22) = 4.87, p = 0.038;
p-cortactin, chronic, F(1,18) = 5.24, p
= 0.039; p-adducin, acute, F(1,23) = 4.36,
p = 0.048. *p < 0.05 comparing repeated
cocaine (Coc/Sa, Coc/Coc) with repeated saline (Sa/Sa, Coc/Sa).
+p < 0.05 comparing acute saline (Sa/Sa, Coc/Sa)
with acute cocaine (Sa/Coc, Coc/Coc).