Inhibition of actin cycling alters F-actin and G-actin. Three weeks after
discontinuing repeated saline or cocaine, rats were injected into the nucleus
accumbens with latrunculin A (0.5 μg) or DMSO (10%) vehicle and killed
immediately or 45 or 135 min later, and the levels of F-actin and G-actin were
examined. Data are shown as mean ± SEM, and the number of determinations is
shown in each bar. Data were evaluated using a one-way ANOVA: cocaine F-actin,
F(2,10) = 6.23, p = 0.020; cocaine
G-actin, F(2,8) = 4.48, p = 0.050.
*p < 0.05 compared with time 0.