Table 2.
Biometric, biochemical and hemodynamic characteristics in aCLD-old rats treated with simvastatin or vehicle.
| Vehicle | Simvastatin | % change | p-value | |
|---|---|---|---|---|
| Body weight (g) | 655 ± 31 | 681 ± 18 | +4 | > 0.20 |
| Liver (g) | 16.6 ± 1.0 | 19.1 ± 1.1 | +15 | 0.15 |
| Liver-body weight ratio (%) | 2.58 ± 0.19 | 2.81 ± 0.15 | +9 | > 0.20 |
| AST (U/L) | 188 ± 34 | 155 ± 28 | -18 | > 0.20 |
| ALT (U/L) | 61 ± 5 | 57 ± 6 | -7 | > 0.20 |
| CKM (ng/mL) | 64 ± 13 | 47 ± 10 | -27 | > 0.20 |
| Bilirubin (mg/dL) | 0.23 ± 0.06 | 0.10 ± 0.00 | -57 | 0.05 |
| Bile production (µL/min*100g bw) | 23.5 ± 7.1 | 42.0 ± 16.5 | +45 | 0.17 |
| Albumin (mg/dL) | 22.0 ± 1.1 | 24.2 ± 0.8 | +10 | 0.10 |
| Plasma cholesterol (mg/dL) | 86 ± 5 | 79 ± 10 | -8 | > 0.20 |
| Plasma LDL cholesterol (mg/dL) | 64 ± 5 | 55 ± 7 | -14 | > 0.20 |
| Plasma HDL cholesterol (mg/dL) | 14.0 ± 1.5 | 15.6 ± 2.6 | +7 | > 0.20 |
| Plasma triglycerides (mg/dL) | 38.0 ± 5.1 | 42.1 ± 7.1 | +11 | > 0.20 |
| Oil red O-staining (%) | 1.33 ± 0.22 | 1.64 ± 0.39 | +23 | > 0.20 |
| MDA (nmol/mg protein) | 2.68 ± 0.74 | 2.35 ± 0.30 | -12 | 0.15 |
| LPS (EU/mL) | 1.49 ± 0.18 | 1.62 ± 0.13 | +8 | > 0.20 |
|
| ||||
| PP (mmHg) | 15.9 ± 1.4 | 11.9 ± 0.8 | -25 | 0.02 |
| PBF (mL/min*g) | 1.28 ± 0.17 | 1.13 ± 0.16 | -12 | >0.20 |
| HVR (mmHg*min/mL*g) | 13.9 ± 2.4 | 12.4 ± 1.5 | -11 | >0.20 |
| Ex vivo HVR (mmHg*min/mL*g) | 0.39 ± 0.04 | 0.32 ± 0.03 | -18 | 0.20 |
| MAP (mmHg) | 97 ± 6 | 110 ± 5 | +13 | >0.20 |
| HR (bpm) | 332 ± 22 | 381 ± 25 | +15 | 0.06 |
Data expressed as mean ± SEM (n = 10 each group).
AST: aspartate transaminase; ALT: alanine transaminase; CKM: Creatinine kinase from muscle; LDL: low density lipoprotein; HDL: high density lipoprotein; MDA: malondialdehyde; LPS: lipopolysaccharide; EU: endotoxin units; PP: portal pressure; PBF: portal blood flow; HVR: hepatic vascular resistance; MAP: mean arterial pressure; HR: heart rate.