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. 2019 Aug 1;10(4):807–817. doi: 10.14336/AD.2018.0728

Figure 3. Necrostatin-1 treatment protected brains against ischemic injury.

Figure 3.

(A) Experimental protocol of necrostatin-1 (Nec-1) treatment in MCAO rats. Nec-1/inactive necrostatin-1 (iNec) were stereotaxically injected to the right lateral ventricle 30 min before MCAO surgery. Rat brains were subjected to reperfusion at 30 min after occlusion of the MCA. Neurological evaluations were performed at 1 h before MCAO (pre-) and 12, 24, 72 h after MCAO. (B) Schematic of the brain shows the injection position of Nec-1/iNec (contralateral ventricle) and the areas of the infarct core (dotted line) after ischemic injury. (C-D) Nec-1 reduced infarct volume at 24 h after MCAO compared with iNec group (n=6-7). (E-F) Nec-1 reduced neurological impairments after cerebral ischemia. The graphs show neurological scores (E) and forelimb placing scores (F) of rats treated with Nec-1 (black bar) or iNec (white bar). **p<0.01.