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. 2019 Aug 1;10(4):807–817. doi: 10.14336/AD.2018.0728

Figure 4. Necrostatin-1 treatment prevented phosphorylation of RIPK1 at Ser166 in neurons after cerebral ischemia.

Figure 4.

(A-B) Nec-1 treatment significantly inhibited ischemia-induced increase of p-RIPK1 expression in the ipsilateral striatum (IPSI) at 24 h after MCAO (compared with iNec treatment, p<0.05, n≥10). (C-D) Nec-1 reduced the number of p-RIPK1-NeuN double positive (p-RIPK1+-NeuN+) neurons in the ipsilateral striatum (IPSI) at 24 h after MCAO (compared with iNec treatment, p<0.05, n=5). CON=contralateral striatum. Scale bars indicate 50 μm.