Figure 6. Partial ATGL inactivation rescues hypertrophy and cardiomyopathy in Bscl2^–/– mice.

(A) Nonfasting plasma insulin levels, (B) ventricle weight (VW) normalized to tibia length (TL), and (C and D) fractional shortening (%) and left ventricle internal diameter at systole (LVIDs, mm). (E and F) Representative Western blotting (E) and fold changes of acetylated lysine (Ac-Lysine) as normalized to GAPDH (F) in whole heart. (G) Cardiac LCAD activity, (H) basal oxygen consumption rate (OCR) in isolated cardiac mitochondria, (I) CO₂ production after incubating heart crude mitochondrial fraction with ¹⁴C-glucose. Six-month-old Atgl^+/+Bscl2^+/+ (A^wB^w), Atgl^+/+Bscl2^–/– (A^wB^k), and Atgl^+/– Bscl2^–/– (A^hB^k) male mice were used, n = 5–12/group. *P < 0.05, **P < 0.005 by one-way ANOVA with Dunnett’s multiple-comparisons correction.