Table 1.
Known and candidate genes for bipolar disorder (BPD) and overlap with schizophrenia and autism.
| Gene symbol | Gene name | Location | Source | ||
|---|---|---|---|---|---|
| ABCA13* | ATP-binding cassette, subfamily A, member 13 | 7p12.3F | Knightet al. (2009) | ||
| ABCCI2 | ATP-binding cassette, subfamily C, member 12 | 16q12.1 | Xu et al. (2014) | ||
| ABHD2 | Abhydrolase domain containing 2 | 15q26.1 | Xu et al. (2014) | ||
| ACACB | Acetyl-coenzyme A carboxylase beta | 12q24.11 | Le-Niculescu et al. (2009) | ||
| ACE* | Angiotensin I converting enzyme | 17q23.3 | Zou et al. (2011) | ||
| ACOXL | Acyl-CoA oxidase-like | 2q13 | Xu et al. (2014) | ||
| ADCY1* | Adenylate cyclase 1 (brain) | 7p12.3 | Le-Niculescu et al. (2009) | ||
| ADCY2 | Adenylate cyclase 2 | 5p15.31 | Mühleisen et al. (2014) | ||
| ADCYAP1* | Adenylate cyclase activating polypeptide 1 (pituitary) | 18p11.32 | Le-Niculescu et al. (2009) | ||
| AFF1 | AF4/FMR2 family, member 1 | 4q21.3 | Xu et al. (2014) | ||
| AGO2 | Argonate RISC catalytic component 2 | 8q24.3 | Le-Niculescu et al. (2009) | ||
| AK3 | Adenylate kinase 3 | 9p24.1 | Le-Niculescu et al. (2009) | ||
| ALDHIAI | Aldehyde dehydrogenase 1 family, member A1 | 9q21.13 | Le-Niculescu et al. (2009) | ||
| ALG9 | ALG9, alpha-1,2-mannosyltransferase | 11q23.1 | Baysal et al. (2002) | ||
| ALKBH8 | AlkB, alkylation repair homolog 8 (Escherichia coli) | 11q22.3 | Xu et al. (2014) | ||
| ANK2# | Ankyrin 2, neuronal | 4q25 | Le-Niculescu et al. (2009) | ||
| ANK3*# | Ankyrin 3 | 10q21.2 | Takata et al. (2011) | ||
| APP# | Amyloid beta (A4) precursor protein | 21q21.3 | Le-Niculescu et al. (2009) | ||
| ARHGAP15# | Rho GTPase activating protein 15 | 2q22.2 | Xu et al. (2014) | ||
| ARNT2# | Aryl-hydrocarbon receptor nuclear translocator 2 | 15q25.1 | Xu et al. (2014) | ||
| ARNTL* | Aryl hydrocarbon receptor nuclear translocator-like | 11p15.3 | Le-Niculescu et al. (2009) | ||
| ASMT# | Acetylserotonin O-methyltransferase | Xp22.33 or Yp11.32 | Etain et al. (2012) | ||
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 12q24.11 | Xu et al. (2014) | ||
| ATXN1* | Ataxin 1 | 6p22.3 | Le-Niculescu et al. (2009) | ||
| BAZ2B | Bromodomain adjacent to zinc finger domain, 2B | 2q24.2 | Xu et al. (2014) | ||
| BCR | Breakpoint cluster region | 22q11.23 | Hashimoto et al. (2005) | ||
| BDNF*# | Brain-derived neurotrophic factor | 11p14.1 | Fan and Sklar (2008) | ||
| BRD1* | Bromodomain containing 1/zinc finger, BED-type containing 4 | 22q13.33 | Nyegaard et al. (2010) | ||
| BRE | Brain and reproductive organ-expressed (TNFRSF1Amodulator) | 2p23.2 | Cichon et al. (2011) | ||
| C9ORF72 | Chromosome 9 open reading frame 72 | 9p212 | Meisler et al. (2013) | ||
| CACNA1C*# | Calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.33 | Ou et al. (2015) | ||
| CACNB2*# | Calcium channel, voltage dependent, beta 2 subunit | 10p12.33 | Le-Niculescu et al. (2009) | ||
| CAMK2A | Calcium/calmodulin-dependent protein kinase II, alpha | 5q32 | Le-Niculescu et al. (2009) | ||
| CAMK2D | Calcium/calmodulin-dependent protein kinase II, delta | 4q26 | Le-Niculescu et al. (2009) | ||
| CAMTA1# | Calmodulin binding transcription activator 1 | 1p36.31 | Cichon et al. (2011) | ||
| CCDC132 | Coiled-coil domain containing 132 | 7q21.3 | Cichon et al. (2011) | ||
| CCDC148 | Coiled-coil domain containing 148 | 2q24.1 | Xu et al. (2014) | ||
| CD36 | CD36 molecule (Thrombospondin receptor) | 7q21.11 | Blair et al. (2006) | ||
| CD44# | CD44 molecule (Indian blood group) | 11p13 | Le-Niculescu et al. (2009) | ||
| CDH7 | Cadherin 7, type 2 | 18q22.1 | Soronen et al. (2010) | ||
| CDH13 | Cadherin 13 | 16q23.3 | Le-Niculescu et al. (2009) | ||
| CDHR3 | Cadherin-related family member 3 | 7q22.3 | Xu et al. (2014) | ||
| CDK14 | Cyclin-dependent kinase 14 | 7q21.13 | Le-Niculescu et al. (2009) | ||
| CELF2 | CUGBP, elav-like family member 2 | 10p13 | Le-Niculescu et al. (2009) | ||
| CELSR1 | Cadherin, EGF LAG seven-pass G-type receptor 1 | 22q13.31 | Le-Niculescu et al. (2009) | ||
| CEP128 | Centrosomal protein 128 kDa | 14q31.1 | Le-Niculescu et al. (2009) | ||
| CFAP57 | Cilia and flagella associated protein 57 | 1p342 | Xu et al. (2014) | ||
| CGRRF1 | Cell growth regulator with ring finger domain 1 | 14q22.2 | Xu et al. (2014) | ||
| CHRNA7*# | Cholinergic receptor, nicotinic, alpha 7 (neuronal) | 15q13.3 | Le-Niculescu et al. (2009) | ||
| CLOCK* | Clock circadian regulator | 4q12 | Benedetti et al. (2003) | ||
| CLSTN2 | Calsyntenin 2 | 3q23 | Le-Niculescu et al. (2009) | ||
| CMIP# | C-Maf inducing protein | 16q23.2 | Xu et al. (2014) | ||
| CNTNAP5*# | Contactin associated protein-like 5 | 2q14.3 | Baum et al. (2008a, 2008b) | ||
| COMT* | Catechol-O-methyltransferase | 22q11.21 | Zhang et al. (2009) | ||
| CREBBP# | CREB binding protein | 16p13.3 | Le-Niculescu et al. (2009) | ||
| CSMD1*# | CUB and sushi multiple domains 1 | 8p23.2 | Sklar et al. (2008) | ||
| DAOA* | D-Amino acid oxidase activator | 13q33.2 | Detera-Wadleigh and McMahon (2006) | ||
| DAPK1 # | Death-associated protein kinase 1 | 9q21.33 | Le-Niculescu et al. (2009) | ||
| DCLK1 | Doublecortin-like kinase 1 | 13q13.3 | Le-Niculescu et al. (2009) | ||
| DCTN5# | Dynactin 5 (P25) | 16p12.2 | Burton et al. (2007) | ||
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | 20q13.13 | Xu et al. (2014) | ||
| DFNB31 | Deafness, autosomal recessive 31 | 9q32 | Ollila et al. (2009) | ||
| DGKH | Diacylglycerol kinase, eta | 13q14.11 | Baum et al. (2008a, 2008b) | ||
| DIAPH1 | Diaphanous-related formin 1 | 5q31.3 | Le-Niculescu et al. (2009) | ||
| DIP2C | Disco-interacting protein 2 homolog C (Drosophila) | 10p15.3 | Djurovic et al. (2010) | ||
| DISC1 *# | Disruption in schizophrenia 1 | 1q42.2 | Hodgkinson et al. (2004) | ||
| DLG2* | Discs, large homolog 2 (Drosophila) | 11q14.1 | Xu et al. (2014) | ||
| DNAJC16 | DnaJ (Hsp40) homolog, subfamily C, member 16 | 1p36.21 | Xu et al. (2014) | ||
| DNMT1 * | DNA methyltransferase 1 | 19p13.2 | Veldic et al.(2005) | ||
| DOCK3 | Dedicator of cytokinesis 3 | 3p212 | Baum et al. (2008a, 2008b) | ||
| DPP10*# | Dipeptidyl-peptidase 10 (non-functional) | 2q14.1 | Le-Niculescu et al. (2009) | ||
| DPY19L3 | Dpy-19-like 3 (Caenorhabditis elegans) | 19q13.11 | Smith et al. (2009) | ||
| DRD2*# | Dopamine receptor D2 | 11q23.2 | Le-Niculescu et al. (2009) | ||
| DRD4* | Dopamine receptor D4 | 11p15.5 | López León et al. (2005) | ||
| DSCAM# | Down syndrome cell adhesion molecule | 21q22.2 | Xu et al. (2014) | ||
| DSEL | Dermatan sulfate epimerase-like | 18q22.1 | Goossens et al. (2003) | ||
| DST# | Dystonin | 6p12.1 | Le-Niculescu et al. (2009) | ||
| DTNBP1* | Dystrobrevin binding protein 1 | 6p22.3 | Gaysina et al. (2009) | ||
| EDAR | Ectodysplasin A receptor | 2q12.3 | Xu et al. (2014) | ||
| EGFEM1P | EGF-Like and EMI domain containing 1, pseudogene | 3q26.2 | Xu et al. (2014) | ||
| EGFR | Epidermal growth factor receptor | 7p11.2 | Sklaret al.(2008) | ||
| EIF2S3# | Eukaryotic translation initiation factor 2, subunit 3 gamma, 52 kDa | Xp22.11 | Cichon et al., (2011) | ||
| ELAVL2 | ELAV like neuron-specific RNA binding protein 2 | 9p21.3 | Le-Niculescu et al. (2009) | ||
| EPHA5 | EPH receptor 5 | 4q13.1 | Le-Niculescu et al. (2009) | ||
| FAM13A1 | Family with sequence similarity 13, member A | 4q22.1 | Le-Niculescu et al. (2009) | ||
| FAM83F | Family with sequence similarity 83, member F | 22q13.1 | Xu et al. (2014) | ||
| FBN1 | Fibrillin 1 | 15q21.1 | Djurovic et al. (2010) | ||
| FBXO28 | F-Box protein 28 | 1q42.11 | Xu et al. (2014) | ||
| FGF12 | Fibroblast growth factor 12 | 3q28 | Cichon et al. (2011) | ||
| FGFR2 | Fibroblast growth factor receptor 2 | 10q26.13 | Xu et al. (2014) | ||
| FGGY | FGGY carbohydrate kinase domain containing | 1p32.1 | Kerner et al. (2013) | ||
| FRMD3 | FERM domain containing 3 | 9q21.32 | Djurovic et al. (2010) | ||
| FOXN3 | Forkhead box N3 | 14q32.11 | Baum et al. (2008a, 2008b) | ||
| FOXP1# | Forkhead box P1 | 3p14.1 | Le-Niculescu et al. (2009) | ||
| FOXP2*# | Forkhead box P2 | 7q31.1 | Xu et al. (2014) | ||
| FUT9 | Fucosyltransferase 9 (alpha (1,3) fucosyltransferase) | 6q16.1 | Le-Niculescu et al. (2009) | ||
| GAA | Glucosidase, alpha; acid | 17q25.3 | Le-Niculescu et al. (2009) | ||
| GABBR2 | Gamma-aminobutyric acid (GABA) B receptor 2 | 9q22.33 | Djurovic et al. (2010) | ||
| GABRB1# | Gamma-aminobutyric acid (GABA) A receptor, beta 1 | 4p12 | Burton et al. (2007) | ||
| GAD2* | Glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa) | 10p11.23 | Heckers et al. (2002) | ||
| GNAI1 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 7q21.11 | Le-Niculescu et al. (2009) | ||
| GNA12 | Guanine nucleotide binding protein (G protein) alpha 12 | 7p22.2 | Le-Niculescu et al. (2009) | ||
| GNAL | Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | 18p11.21 | Corradi et al. (2005) | ||
| GNG4 | Guanine nucleotide binding protein (G protein), gamma 4 | 1q42.3 | Cichon et al. (2011) | ||
| GPR50* | G protein-coupled receptor 50 | Xq28 | Thomson et al. (2005) | ||
| GRIA1* | Glutamate receptor, ionotropic, AMPA1 (alpha 1) | 5q33.2 | Le-Niculescu et al. (2009) | ||
| GRIK1 | Glutamate receptor, ionotropic, kainate 1 | 21q21.3 | Le-Niculescu et al. (2009) | ||
| GRIK2# | Glutamate receptor, ionotropic, kainite 2 | 6q16.3 | Shaltiel et al. (2008) | ||
| GRIK4* | Glutamate receptor, ionotropic, kainite 4 | 11q23.3 | Blackwood et al. (2007) | ||
| GRIN3A* | Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | 9q31.1 | Cichon et al. (2011) | ||
| GRM1# | Glutamate receptor, metabotropic 1 | 6q24.3 | Le-Niculescu et al. (2009) | ||
| GRM3* | Glutamate receptor, metabotropic 3 | 7q21.11 | Le-Niculescu et al. (2009) | ||
| GRM7* | Glutamate receptor, metabotropic 7 | 3p26.1 | Burton et al. (2007) | ||
| GSK3B*# | Glycogen synthase kinase 3 beta | 3q13.33 | Le-Niculescu et al. (2009) | ||
| GSTA2 | Glutathione S-transferase alpha 2 | 6p12.2 | Le-Niculescu et al. (2009) | ||
| GUCA1A | Guanylate cyclase activator 1 A | 6p21.1 | Xu et al. (2014) | ||
| HMOX1 | Heme oxygenase 1 | 22q12.3 | Le-Niculescu et al. (2009) | ||
| HTR1A* | 5-Hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 5q12.3 | Kishi et al. (2011) | ||
| HTR2A*# | 5-Hydroxytryptamine (serotonin) receptor 2A, G-protein-coupled | 13q14.2 | Le-Niculescu et al. (2009) | ||
| HTR3B* | 5-Hydroxytryptamine (serotonin) receptor 3B, ionotropic | 11q23.1 | Hammer et al. (2012) | ||
| HTR4* | 5-Hydroxytryptamine (serotonin) receptor 4, G-protein coupled | 5q32 | Ohtsuki et al. (2002) | ||
| ICAM3 | Intercellular adhesion molecule 3 | 19p13.2 | Cichon et al. (2011) | ||
| IGFBP7 | Insulin-like growth factor binding protein 7 | 4q12 | Xu et al. (2014) | ||
| IGSF21 | Immunoglobin superfamily, member 21 | 1p36.13 | Cichon et al. (2011) | ||
| IMPA2* | Myo-inositol monophosphatase 2 | 18p11.21 | Sjøholt et al. (2004) | ||
| IMPG1 | Interphotoreceptor matrix proteoglycan 1 | 6q14.1 | Xu et al. (2014) | ||
| INO80 | INO80 complex subunit | 15q15.1 | Xu et al. (2014) | ||
| IQGAP2 | IQmotif containing GTPase activating protein 2 | 5q13.3 | Le-Niculescu et al. (2009) | ||
| ITGAV | Integrin, alpha V | 2q32.1 | Le-Niculescu et al. (2009) | ||
| ITIH3* | Inter-alpha-trypsin inhibitor, heavy chain 3 | 3p21.1 | Hamshere et al. (2013) | ||
| JAK1 | Janus kinase 1 | 1p31.3 | Xu et al. (2014) | ||
| JAM3 | Junctional adhesion molecule 3 | 11q25 | Baum et al. (2008a, 2008b) | ||
| KCNAB1 | Potassium channel, voltage gated subfamily A regulatory beta subunit 1 | 3q25.31 | Le-Niculescu et al. (2009) | ||
| KCNB1 | Potassium channel, voltage gated Shab-related subfamily B, member 1 | 20q13.2 | Le-Niculescu et al. (2009) | ||
| KCNC2 | Potassium channel, voltage gated Shaw related subfamily C, member 2 | 12q14.1 | Burton et al. (2007) | ||
| KCND2# | Potassium voltage-gated channel, Shal-related family, member 2 | 7q31.31 | Le-Niculescu et al. (2009) | ||
| KCNIP4 | Kv channel interacting protein 4 | 4p15.32 | Xu et al. (2014) | ||
| KCNK1 | Potassium channel, subfamily K, member 1 | 1q422 | Le-Niculescu et al. (2009) | ||
| KHDC1 | KH homology domain containing 1 | 6q13 | Xu et al. (2014) | ||
| KIAA1462 | KIAA1462 gene | 10p11.23 | Xu et al. (2014) | ||
| KIF13B | Kinesin family member 13B | 8p12 | Xu et al. (2014) | ||
| KLF12 | Kruppel-like factor 12 | 13q22.1 | Le-Niculescu et al. (2009) | ||
| KIF1A | Kinesin family member 1 A | 2q37.3 | Le-Niculescu et al. (2009) | ||
| KLHL3 | Kelch-like family member 3 | 5q312 | Cichon et al. (2011) | ||
| KLHL20 | Kelch-like family member 20 | 1q25.1 | Xu et al. (2014) | ||
| LARGE | Like-glycosyltransferase | 22q12.3 | Le-Niculescu et al. (2009) | ||
| LDLRAD4 | Low density lipoprotein receptor class A domain containing 4 | 18p11.21 | Le-Niculescu et al. (2009) | ||
| LEF1 | Lymphoid enhancer-binding factor 1 | 4q25 | Le-Niculescu et al. (2009) | ||
| LHFPL3 | Lipoma HMGIC fusion partner-like 3 | 7q22.2 | Cichon et al. (2011) | ||
| LMO7 | LIM domain 7 | 13q22.2 | Le-Niculescu et al. (2009) | ||
| LMOD3 | Leiomodin 3 | 3p14.1 | Xu et al. (2014) | ||
| LRRC74A | Leucine rich repeat containing 74A | 14q24.3 | Xu et al. (2014) | ||
| LRRFIP1 | Leucine rich repeat (In FLII) interacting protein 1 | 2q37.3 | Xu et al. (2014) | ||
| LYPD5 | LY6/PLAUR domain containing 5 | 19q13.31 | Cichon et al. (2011) | ||
| MACROD1 | MACRO domain containing 1 | 11q13.1 | Cichon et al. (2011) | ||
| MAD1L1* | MAD1 mitotic arrest deficient-like 1 (yeast) | 7p22.3 | Cichon et al. (2011) | ||
| MAOA*# | Monoamine oxidase A | Xp11.3 | Fan et al. (2010) | ||
| MARCH1 | Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase | 4q32.2 | Xu et al. (2014) | ||
| MBNL2 | Musclebind-like splicing regulator 2 | 13q32.1 | Le-Niculescu et al. (2009) | ||
| MBP | Myelin basic protein | 18q23 | Le-Niculescu et al. (2009) | ||
| MDH1 | Malate dehydrogenase 1, NAD (soluble) | 2p13.3 | Le-Niculescu et al. (2009) | ||
| MFSD11 | Major facilitator superfamily domain containing 11 | 17q25.1 | Xu et al. (2014) | ||
| MTHFR*# | Methylenetetrahydrofolate reductase (NAD(P)H) | 1p36.22 | El-Hadidy et al. (2014) | ||
| MTMR3 | Myotubularin related protein 3 | 22q12.2 | Xu et al. (2014) | ||
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 13q22.3 | Le-Niculescu et al. (2009) | ||
| MYO5B | Myosin VB | 18q21.1 | Sklar et al. (2008) | ||
| MYO18B | Myosin XVIIIB | 22q12.1 | Xu et al. (2014) | ||
| MYT1L# | Myelin transcription factor 1-like | 2p25.3 | Le-Niculescu et al. (2009) | ||
| NAALAD2 | N-acetylated alpha-linked acidic dipeptidase 2 | 11q14.3 | Xu et al. (2014) | ||
| NALCN* | Sodium leak channel, non-selective | 13q32.3 | Sklar et al. (2008) | ||
| NAV2 | Neuron navigator 2 | 11p15.1 | Le-Niculescu et al. (2009) | ||
| NCALD | Neurocalcin delta | 8q22.3 | Xu et al. (2014) | ||
| NCAM1* | Neural cell adhesion molecule 1 | 11q23.2 | Le-Niculescu et al. (2009) | ||
| NCAN | Neurocan | 19p12 | Cichon et al. (2011) | ||
| NCKAP5# | NCK-associated protein 5 | 2q21.2 | Smith et al. (2009) | ||
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8 kDa | 16p12.2 | Burton et al. (2007) | ||
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2,49 kDa (NADH-coenzyme Qreductase) | 1q23.3 | Le-Niculescu et al. (2009) | ||
| NFIA# | Nuclear factor I/A | 1p31.3 | Le-Niculescu et al. (2009) | ||
| NFIB | Nuclear factor I/B | 9p24.1 | Le-Niculescu et al. (2009) | ||
| NIPBL | Nipped-B homolog (Drosophila) | 5p132 | Xu et al. (2014) | ||
| NME7 | NME/NM23 family member 7 | 1q24.2 | Xu et al. (2014) | ||
| NOS1AP*# | Nitric oxide synthase 1 (neuronal) adaptor protein | 1q23.3 | Xu et al. (2014) | ||
| NPAS3* | Neuronal PAS domain protein 3 | 14q13.1 | Pickard et al. (2009) | ||
| NPFFR2 | Neuropeptide FF receptor 2 isoform 1 | 4q13.3 | Xu et al. (2014) | ||
| NR3C1 | Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5q31.3 | Le-Niculescu et al. (2009) | ||
| NRCAM# | Neuronal cell adhesion molecule | 7q31.1 | (Le-Niculescu et al., (2009) | ||
| NRG1 *# | Neuregulin 1 | 8p12 | Prata et al. (2009) | ||
| NRG3* | Neuregulin 3 | 10q23.1 | Xu et al. (2014) | ||
| NTF3* | Neurotrophin 3 | 12p13.31 | Cichon et al. (2011) | ||
| NTRK2* | Neurotrophic tyrosine kinase, receptor, type 2 | 9q21.33 | Smith et al. (2009) | ||
| NUP214 | Nucleoporin 214 kDa | 9q34.13 | Xu et al. (2014) | ||
| OC90 | Otoconin 90 | 8q24.22 | Xu et al. (2014) | ||
| OLIG2* | Oligodendrocyte lineage transcription factor 2 | 21q22.11 | Le-Niculescu et al. (2009) | ||
| OPRM1 # | Opioid receptor, mu 1 | 6q25.2 | Le-Niculescu et al. (2009) | ||
| OR1B1 | Olfactory receptor, family 1, subfamily B, member 1 | 9q33.2 | Xu et al. (2014) | ||
| PALB2 | Partner and localizer of BRCA2 | 16p12.2 | Tesli et al. (2010) | ||
| PARD3 | Par-3 family cell polarity regulator | 10p11.21 | Le-Niculescu et al. (2009) | ||
| PARD3B# | Par-3 family cell polarity regulator beta | 2q33.3 | Cichon et al. (2011) | ||
| PCDHAC2# | Protocadherin-alpha, subfamily C, 2 | 5q31.3 | Pedrosa et al. (2008) | ||
| PCDH7 | Protocadherin 7 | 4p15.1 | Le-Niculescu et al. (2009) | ||
| PCDH9# | Protocadherin 9 | 13q21.32 | Le-Niculescu et al. (2009) | ||
| PCLO | Piccolo presynaptic cytomatrix protein | 7q21.11 | Choi et al. (2011) | ||
| PDE10A | Phosphodiesterase 10 A | 6q26 | Le-Niculescu et al. (2009) | ||
| PDE4B*# | Phosphodiesterase 4B, CAMP-specific | 1p31.3 | Xu et al. (2014) | ||
| PER3* | Period circadian clock 3 | 1p3623 | Benedetti et al. (2008) | ||
| PDLIM5* | PDZ and LIM domain 5 | 4q22.3 | Shi et al. (2008) | ||
| PHF20 | PHD finger protein 20 | 20q11.22 | Xu et al. (2014) | ||
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Le-Niculescu et al. (2009) | ||
| PLCL2 | Phospholipase C-like 2 | 3p24.3 | Xu et al. (2014) | ||
| PLXNA2* | Plexin A2 | 1q32.2 | Le-Niculescu et al. (2009) | ||
| PPM1B | Protein phosphatase, Mg2+/Mn2+ dependent, 1B | 2p22.1 | Le-Niculescu et al. (2009) | ||
| PPP2R2A | Protein phosphatase 2, regulatory subunit B, alpha | 8p212 | Xu et al. (2014) | ||
| PPP2R2C | Protein phosphatase 2, regulatory subunit B, gamma | 4p16.1 | Baum et al. (2008a, 2008b) | ||
| PRKCE | Protein kinase C, epsilon | 2p21 | Le-Niculescu et al. (2009) | ||
| PRPF18 | Pre-MRNA processing factor 18 | 10p12.33 | Xu et al. (2014) | ||
| PRR16 | Proline rich 16 | 5q23.1 | Xu et al. (2014) | ||
| PRSS55 | Protease, serine, 55 | 8p23.1 | Xu et al. (2014) | ||
| PTN | Pleiotrophin | 7q33 | Le-Niculescu et al. (2009) | ||
| PTPRK | Protein tyrosine phosphatase, receptor type, K | 6q22.33 | Le-Niculescu et al. (2009) | ||
| PTPRM# | Protein tyrosine phosphatase, receptor type, M | 18p11.23 | Le-Niculescu et al. (2009) | ||
| PTPRO | Protein tyrosine phosphatase, receptor type, O | 12p12.3 | Xu et al. (2014) | ||
| PYDC2 | Pyrin domain containing 2 | 3q28 | Cichon et al. (2011) | ||
| QKI* | Quaking homolog, KH domain RNA binding | 6q26 | Le-Niculescu et al. (2009) | ||
| RABEP1 | Rabaptin, RAB GTPase binding effector protein 1 | 17p13.2 | Djurovic et al. (2010) | ||
| RABGAP1L | RAB GTPase activating protein 1-like | 1q25.1 | Xu et al. (2014) | ||
| RAD51L1 | RAD51, paralog B | 14q24.1 | Xu et al. (2014) | ||
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 5q14.1 | Le-Niculescu et al. (2009) | ||
| RBFOX1 # | RNAbindingprotein, fox-1 homolog (C. elegans) 1 | 16p13.3 | Le-Niculescu et al. (2009) | ||
| RBM23 | RNA binding motif protein 23 | 14q11.2 | Xu et al. (2014) | ||
| RC3H1 | Ring finger and CCCH-type domains 1 | 1q25.1 | Xu et al. (2014) | ||
| RLF | Rearranged L-Myc fusion | 1p34.2 | Xu et al. (2014) | ||
| RORA# | RAR-related orphan receptor alpha | 15q22.2 | Le-Niculescu et al. (2009) | ||
| RORB | RAR-related orphan receptor beta | 9q21.13 | Le-Niculescu et al. (2009) | ||
| RSPO4 | R-spondin 4 | 20p13 | Xu et al. (2014) | ||
| RXRG | Retinoid × receptor, gamma | 1q23.3 | Le-Niculescu et al. (2009) | ||
| RYR3 | Ryanodine receptor 3 | 15q13.3 | Le-Niculescu et al. (2009) | ||
| SCAMP1 | Secretory carrier membrane protein 1 | 5q14.1 | Le-Niculescu et al. (2009) | ||
| SCN7A# | Sodium channel, voltage gated, type VII alpha subunit | 2q24.3 | Xu et al. (2014) | ||
| SHISA9 | Shisa family member 9 | 16p13.12 | Xu et al. (2014) | ||
| SLC39A3 | Solute carrier family 39 (Zinc transporter), member 3 | 19p13.3 | Baum et al. (2008a, 2008b) | ||
| SLC6A3*# | Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 5p15.33 | Greenwood et al. (2006) | ||
| SLC8A1 | Solute carrier family 8 (sodium/calcium exchanger), member 1 | 2p22.1 | Le-Niculescu et al. (2009) | ||
| SOD1 # | Superoxide dismutase 1, soluble | 21q22.11 | Le-Niculescu et al. (2009) | ||
| SORCS2 | Sortilin-related VPS10 domain containing receptor 2 | 4p16.1 | Soronen et al. (2010) | ||
| SPAG16 | Sperm associated antigen 16 | 2q34 | Xu et al. (2014) | ||
| SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | 5q31.3 | Le-Niculescu et al. (2009) | ||
| SPAST# | Spastin | 2q22.3 | Le-Niculescu et al. (2009) | ||
| STAB1 | Stabilin 1 | 3p21.1 | Baum et al. (2008a, 2008b) | ||
| STK24 | Serine/threonin kinase 24 | 13q32.2 | Le-Niculescu et al. (2009) | ||
| STX12 | Syntaxin 12 | 1p35.3 | Xu et al. (2014) | ||
| SVIL | Supervillin | 10p11.23 | Purcell et al. (2009) | ||
| SYN3*# | Synapsin III | 22q12.3 | Le-Niculescu et al. (2009) | ||
| SYNE1 # | Spectrin repeat containing, nuclear envelope 1 | 6q252 | Ferreira et al. (2008) | ||
| TBC1D22B | TBC1 domain family, member 22B | 6p21.2 | Xu et al. (2014) | ||
| TBXAS1 | Thromboxane A synthase 1 | 7q34 | Xu et al. (2014) | ||
| TCF4*# | Transcription factor 4 | 18q21.1 | Del-Favero et al. (2002) | ||
| TEAD1 | TEA domain family member 1 | 11p15.4 | Xu et al. (2014) | ||
| TENM4 | Teneurin transmembrane protein 4 | 11q14.1 | Sklar et al., 2011 | ||
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 21q22.11 | Le-Niculescu et al. (2009) | ||
| TLE4 | Transducin-like enhancer ofsplit 4 | 9q21.31 | Cichon et al. (2011) | ||
| TMEM252 | Transmembrane protein 252 | 9q21.11 | Xu et al. (2014) | ||
| TNIK | TRAF2 and NCK interacting kinase | 3q26.31 | Le-Niculescu et al. (2009) | ||
| TPH1 | Tryptophan hydroxylase 1 | 11p15.1 | Chen et al. (2012) | ||
| TPH2*# | Tryptophan hydroxylase 2 | 12q21.1 | Cichon et al. (2008) | ||
| TPST2 | Tyrosylprotein sulfotransferase 2 | 22q12.1 | Le-Niculescu et al. (2009) | ||
| TRANK1 | Tetratricopeptide repeat and ankyrin repeat containing 1 | 3p22.2 | Mühleisen et al. (2014) | ||
| TRIO# | Trio rho guanine nucleotide exchange factor | 5p15.2 | Xu et al. (2014) | ||
| TRPM2 | Transient receptor potential cation channel, subfamily M, member 2 | 21q22.3 | McQuillin et al. (2006) | ||
| TRPM3 | Transient receptor potential cation channel, subfamily M, member 3 | 9q21.12 | Le-Niculescu et al. (2009) | ||
| TRPV3 | Transient receptor potential cation channel, subfamily V member 3 | 17p13.2 | Cichon et al. (2011) | ||
| TRRAP | Transformation/transcription domain-associated protein | 7q22.1 | Xu et al. (2014) | ||
| TSHZ2 | Teashirt zinc finger homeobox 2 | 20q13.2 | Le-Niculescu et al. (2009) | ||
| TSPAN8 | Tetraspanin 8 | 12q21.1 | Scholz et al. (2010) | ||
| VAMP7 | Vesicle-associated membrane protein 7 | Xq28 or Yq12 | Saito et al. (2000) | ||
| VIP# | Vasoactive Intestinal Peptide | 6q252 | Soria et al. (2010) | ||
| WDR60 | WD repeat domain 60 | 7q36.3 | Xu et al. (2014) | ||
| WDR7 | WD repeat domain 7 | 18q21.31 | Xu et al. (2014) | ||
| WNK2 | WNK lysine deficient protein kinase 2 | 9q22.31 | Cichon et al. (2011) | ||
| XBP1* | X box-binding protein 1 | 22q12.1 | Kakiuchi et al. (2003) | ||
| XKR4* | XK, Kell blood group complex subunit-related family, member 4 | 8q12.1 | Djurovic et al. (2010) | ||
| XXYLT1 | Xyloside xylosyltransferase 1 | 3q29 | Xu et al. (2014) | ||
| ZEB2* | Zinc finger E-box binding homeobox 2 | 2q22.3 | Cichon et al. (2011) | ||
| ZBTB20# | Zinc finger and BTB domain containing 20 | 3q13.31 | Xu et al. (2014) | ||
| ZDHHC14 | Zinc finger, DHHC-type containing 14 | 6q25.3 | Le-Niculescu et al. (2009) | ||
| ZHX2 | Zinc fingers and homeoboxes 2 | 8q24.13 | Le-Niculescu et al. (2009) | ||
| ZNF274 | Zinc finger protein 274 | 19q13.43 | Xu et al. (2014) | ||
| ZNF385D* | Zinc finger protein 385D | 3p24.3 | Xu et al. (2014) | ||
| ZNF536 | Zinc finger protein 536 | 19q13.11 | Djurovic et al. (2010) | ||
| ZNF618 | Zinc finger protein 618 | 9q33.1 | Cichon et al. (2011) | ||
| ZNF804A*# | Zinc finger protein 804 A | 2q32.1 | Williams et al.(2011) | ||
*
denotes BPD genes that overlap with clinically relevant genes for schizophrenia.
#
denotes BPD genes that overlap with clinically relevant genes for autism spectrum disorder.