Table 2. Multivariable-adjusted HRs (95% CIs) for incident ischemic stroke by lifestyle factors among 461,211 participants.

(ncase = 19,348)	Cases	Cases/PYs (/1,000)	HR (95% CI)	Ptrend*
Smoking
Never	12,141	5.5	1.00
Former	839	9.3	0.98 (0.91, 1.06)
Current (cigarettes/day)
< 15	2,756	7.9	1.17 (1.11, 1.23)	0.018
15 -	2,655	6.1	1.22 (1.16, 1.29)
25 -	957	5.6	1.22 (1.13, 1.31)
Alcohol consumption
Never	15,230	5.7	1.00
Former	1,111	9.7	1.24 (1.16, 1.32)
Current weekly	1,079	5.5	0.90 (0.84, 0.96)
Current daily (g/day)
< 15	170	11.0	0.94 (0.81, 1.10)	0.029
15 -	422	7.4	0.90 (0.81, 0.99)
30 -	680	7.0	1.00 (0.92, 1.09)
60 -	656	5.1	1.06 (0.97, 1.15)
Physical activity (MET-hours/day)
< 11.0	8,713	11.2	1.00	<0.001
11.0 -	5,482	6.5	0.92 (0.89, 0.96)
Men 20.0 -, Women 18.0 -	2,994	3.6	0.89 (0.85, 0.93)
Men 33.5 -, Women 29.5 -	2,159	2.6	0.84 (0.79, 0.88)
Dietary pattern
Daily FV, weekly but not daily meat	1,397	6.6	1.00	--
Less than daily FV, daily meat	133	8.9	1.35 (1.12, 1.61)
Other	17,818	5.9	1.13 (1.07, 1.20)
BMI (kg/m2)
< 18.5	786	5.5	0.94 (0.88, 1.02)	<0.001
18.5 -	8,756	5.0	1.00
24.0 -	7,136	6.7	1.09 (1.05, 1.13)
28.0 -	2,670	8.4	1.14 (1.09, 1.20)
WHR
Men < 0.90, women < 0.85	6,712	4.7	1.00	<0.001
Men 0.90 -, women 0.85 -	5,690	6.2	1.12 (1.08, 1.16)
Men 0.95 -, women 0.90 -	6,946	7.6	1.15 (1.11, 1.20)

HR indicates hazard ratio; CI, confidence interval; PYs, person-years; MET, metabolic equivalent task; FV: fruits and vegetables; BMI, body mass index; and WHR, waist-to-hip ratio. Multivariable model was adjusted for age, sex, education, marital status, family history of stroke, and prevalent hypertension at baseline. All six lifestyle factors were included simultaneously in the same model.

^*Linear trend test for smoking was only performed in current smokers and alcohol consumption in current daily drinkers.