. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: J Alzheimers Dis. 2019;69(1):111–121. doi: 10.3233/JAD-180291

Table 4.

Association between sleep problems and CSF biomarkers

CSF Biomarker	SPI Score
CSF Biomarker	β (SE)	p
Aβ₄₂	−5.23 (29.95)	.862
t-tau	26.30 (15.71)	.099
p-tau	4.49 (1.98)	.027
t-tau/Aβ₄₂	.11 (.05)	.021
p-tau/Aβ₄₂	.02 (.01)	.009

Models were adjusted for age at GXT, sex, APOE ε4 status, and time interval between sleep and CSF assessments.

CSF=cerebrospinal fluid; SPI=Sleep Problems Index I; β=regression estimate; SE=standard error; Aβ₄₂=amyloid-beta 42; t-tau=total tau; p-tau=phosphorylated tau; GXT=graded exercise test; APOE ε4= the ε4 allele of the apolipoprotein E gene