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. 2019 May 27;104(8):1306–1323. doi: 10.1113/EP087700

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© 2019 The Authors. Experimental Physiology Published by John Wiley & Sons Ltd on behalf of The Physiological Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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graphic file with name EPH-104-1306-g005.jpg — Effect of selective afferent renal nerve ablation on the cardiovascular, renal, and PVN neuronal responses to an acute 1 m NaCl infusion. (a) Cardiovascular and renal responses to a 2 h 1 m NaCl infusion in conscious male Sprague–Dawley (SD) rats 10 days after a selective afferent renal nerve ablation (ADNX) or sham ADNX procedure. (b) Neuronal activation (c‐fos‐positive cell count) assessed after a 120 min sodium load or a 2 h surgical recovery and control period (baseline group) in the lateral parvocellular, ventrolateral parvocellular, magnocellular, medial parvocellular and dorsal parvocellular regions of the paraventricular nucleus of the hypothalamus following 1 m NaCl infusion in conscious male SD rats 10 days after sham or ADNX procedure. (c) Representative images from level 2 of the PVN. (d) Renal pelvic pressure in a separate group of anaesthetized male SD rats during a 1 h control isotonic saline infusion (20µl min⁻¹) and a 2 h 1 m NaCl infusion (20 µl min⁻¹). n = 6/group. *P < 0.05 vs. group baseline value, denoted C. C_H2O, free water clearance; GFR, glomerular filtration rate; HR, heart rate; MAP, mean arterial pressure; RPF, renal plasma flow; U _Na V, urinary sodium excretion; V, urinary flow rate

graphic file with name EPH-104-1306-g006.jpg — Effect of selective afferent renal nerve ablation on the cardiovascular, renal, and PVN neuronal responses to an acute 1 m NaCl infusion. (a) Cardiovascular and renal responses to a 2 h 1 m NaCl infusion in conscious male Sprague–Dawley (SD) rats 10 days after a selective afferent renal nerve ablation (ADNX) or sham ADNX procedure. (b) Neuronal activation (c‐fos‐positive cell count) assessed after a 120 min sodium load or a 2 h surgical recovery and control period (baseline group) in the lateral parvocellular, ventrolateral parvocellular, magnocellular, medial parvocellular and dorsal parvocellular regions of the paraventricular nucleus of the hypothalamus following 1 m NaCl infusion in conscious male SD rats 10 days after sham or ADNX procedure. (c) Representative images from level 2 of the PVN. (d) Renal pelvic pressure in a separate group of anaesthetized male SD rats during a 1 h control isotonic saline infusion (20µl min⁻¹) and a 2 h 1 m NaCl infusion (20 µl min⁻¹). n = 6/group. *P < 0.05 vs. group baseline value, denoted C. C_H2O, free water clearance; GFR, glomerular filtration rate; HR, heart rate; MAP, mean arterial pressure; RPF, renal plasma flow; U _Na V, urinary sodium excretion; V, urinary flow rate