Figure 4.
Effect of high salt intake on afferent renal nerve responsiveness. (a) Ex vivo renal pelvis substance P release (pg min−1) in response to 1250 pm noradrenaline (NA) on day 21 of a normal salt (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet in male Sprague–Dawley (SD), Dahl salt‐resistant (DSR), and Dahl salt‐sensitive (DSS) rats. (b,c) Urinary sodium excretion (U Na V) in response to graded increases in renal pelvic pressure in male SD (b) and DSS (c) rats following a 21 day NS or HS diet. (d) Ex vivo renal pelvis substance P release in response to 450 mm NaCl on day 21 of a NS or HS diet in male SD, DSR and DSS rats. (e,f) Urinary sodium excretion in response to increased renal pelvic sodium concentration in male SD (e) and DSS (f) rats. n = 6/group. *P < 0.05 vs. group baseline U Na V with renal pelvic pressure at 0 mmHg, †P < 0.05 vs. respective NS group value