Figure 5.

Effect of selective afferent renal nerve ablation on the cardiovascular, renal and sympathetic responses to high salt intake in Sprague–Dawley rats. (a–c) Daily mean arterial pressure (MAP) (a), 24 h urine volume (b), and 24 h sodium balance (meq) (c) in male Sprague–Dawley rats that underwent sham ADNX or ADNX immediately prior to a 21 day experimental normal salt (NS; 0.6% NaCl) or high salt (HS; 4% NaCl) diet. (d–g) Renal noradrenaline (NA) content (d), plasma NA concentration (e), plasma renin activity (PRA; angiotensin I (ang I) generation) (f) and urinary angiotensinogen (UAGT) (g) on day 21 of NS or HS intake. n = 6/group. *P < 0.05 vs. baseline (NS intake); †P < 0.05 vs. respective sham ADNX group