Figure 6.

Expression of BIRC3 in breast cancer cells and tissues. A, BIRC3 mRNA and protein expression were higher in TNBC cell lines than in normal breast epithelial cell line MCF‐10A and other breast cancer cell lines. ** P < 0.01, two‐sided Student's t test; n = 3. B, IHC showed that BIRC3 expression was significantly upregulated in TNBC tissues than in adjacent normal tissues and other breast cancer subtype tissues (up × 100; bottom × 400). C, IHC analysis of xenografted tumor tissues revealed that BIRC3 expression was decreased in the HCP5 knockdown groups (×400). D, BIRC3 expression was higher in basal‐like breast cancers than in normal breast tissues and other subtypes from TCGA database