Figure 2.

The expression of CD47 in cancer cells. (A) A high expression level of CD47 is correlated to poor prognosis in cancers. (B) Outline of the currently known mechanisms inducing the overexpression of CD47 in cancer cells. Following activation by extracellular TNF‐α, NF‐κB binds to a super‐enhancer to promote the expression of CD47. Transcription factors enhance the expression of CD47 by directly binding to the promoter of CD47. The expression of tumor suppressor miR‐133a is downregulated in cancers, leading to the decreased expression of CD47 by binding to the 3 prime untranslated region of CD47 mRNA