Table 1.
Pharmacokinetic parameters of RANCE‐1 after single ip injection in tumor‐bearing mice
| Parameters | RANCE‐1 |
|---|---|
| Dose | 10 mg/kg, ip |
| Tmax (h) | 10.00 ± 3.46 |
| Cmax (µg/mL) | 22.60 ± 2.58 |
| AUC0‐72h (µg h/mL) | 792.9 ± 270.3 |
| ke (h‐1) | 0.0196 ± 0.0088 |
| t1/2 (h) | 40.77 ± 18.67 |
| Vd/F (mL/Kg) | 612.10 ± 429.00 |
| Cl/F (mL/h/Kg) | 10.00 ± 3.15 |
| Cminss (µg/mL)a | 7.17 ± 3.91 |
| Time to reach steady state (h) | 203.8 ± 93.4 |
Pharmacokinetic parameters determined include the maximum observed plasma concentration (Cmax), the time to reach Cmax (Tmax), area under the plasma concentration–time curve from time zero to 72 h post dose (AUC0‐72h), elimination rate constant (ke), terminal elimination half‐life (t1/2), apparent total clearance from plasma (Cl/F), apparent volume of distribution (Vd/F), and minimum plasma drug concentrations at steady state (Cminss).
a
The predicted Cminss is based on a dose of 10 mg/kg every 72 h.