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Schematic representation of Gal‐3 contribution to ovarian cancer progression through induced STAT3 activity. We hypothesize from our study here and other reports24, 41 that Gal‐3 could establish a reinforcing STAT3‐HIF‐1α positive feedback loop through cytokines (left) and/or integrins (right) leading to increased levels of Gal‐3 which results to increased cell survival, proliferation, chemoresistance, migration, and invasion of ovarian cancer cells
