Table 3.

Univariate and multivariate relapse‐free and overall survival analysis

Characteristics	Relapse‐free survival						Overall survival
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Gender
Female	ref	–	–				ref	–	–
Male	1.082	0.748‐1.564	0.677				1.135	0.740‐1.741	0.561
Age (year)
≤60	ref	–	–	ref	–	–	ref	–	–	ref	–	–
>60	1.75	1.210‐2.532	0.003	1.916	1.319‐2.789	0.001	1.956	1.277‐2.997	0.002	1.843	1.186‐2.865	0.007
GI‐bleeding
No	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Yes	0.578	0.371‐0.900	0.015	0.472	0.299‐0.745	0.001	0.444	0.254‐0.776	0.004	0.441	0.250‐0.776	0.005
Tumor location			<0.001			<0.001			0.041			0.056
Stomach	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Small intestine	2.062	1.415‐3.007	<0.001	2.075	1.397‐3.083	<0.001	1.565	0.998‐2.454	0.051	1.561	0.974‐2.501	0.064
Colorectum	2.389	1.243‐4.580	0.009	2.600	1.339‐5.047	0.005	2.196	1.062‐4.540	0.034	2.144	1.026‐4.481	0.042
Tumor size (cm)			<0.001			<0.001			<0.001			0.004
≤5	ref	–	–	ref	–	–	ref	–	–	ref	–	–
5‐10	2.914	1.928‐4.405	<0.001	2.331	1.497‐3.630	<0.001	2.366	1.449‐3.863	0.001	2.356	1.402‐3.960	0.001
>10	3.777	2.348‐6.078	<0.001	2.128	1.267‐3.574	0.004	3.486	2.003‐6.068	<0.001	2.064	1.114‐3.824	0.021
Mitotic index			<0.001			<0.001			<0.001			<0.001
≤5/50 HPF	ref	–	–	ref	–	–	ref	–	–	ref	–	–
6‐10/50 HPF	2.749	1.735‐4.354	<0.001	2.080	1.284‐3.368	0.003	2.374	1.340‐4.208	0.003	2.153	1.187‐3.904	0.012
>10/50 HPF	4.896	2.821‐8.499	<0.001	4.243	2.357‐7.640	<0.001	6.81	3.682‐12.593	<0.001	6.966	3.558‐13.641	<0.001
Tumor rupture
No	ref	–	–	ref	–	–	ref	–	–
Yes	5.277	1.929‐14.435	0.001	2.697	0.945‐7.694	0.064	1.651	0.229‐11.897	0.619
Adjuvant imatinib
No	ref	–	–	ref	–	–	ref	–	–	ref	–	–
Yes	1.575	1.069‐2.321	0.021	0.946	0.618‐1.448	0.797	0.779	0.451‐1.345	0.37	0.465	0.262‐0.826	0.009

Abbreviations: CI, confidence interval; GI, gastrointestinal; HPF, high‐powered fields; HR, hazard ratio.