Figure 3.

Comparison and combination of doxorubicin (Dox) and mEHT treatments in C26 tumor cell cultures. 1 µmol/L Dox, reducing cell viability (resazurin assay) by ~40%, was chosen for further investigations (A). Progressively and significantly reduced tumor cell viability (B) and numbers (C) 24 and 48 h after mEHT, Dox and combined (mEHT + Dox) treatments. Enhanced effect of the combined treatment might be due to the reduced Dox concentration (elevated Dox uptake) in the culture supernatants (D). **P < 0.01; ***P < 0.001