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. 2019 Aug 2;10(8):576. doi: 10.1038/s41419-019-1814-8

Fig. 8. circHECTD1 exerted tumor-promoting effects in GC in vivo.

Fig. 8

a Xenograft mouse models were used to assess the effects of circHECTD1 on GC growth. Nude mice were injected subcutaneously with GC cells with circHECTD1 knockdown or overexpression and corresponding control cells. The xenografts were harvested after 1 month. b The volumes of the xenografts were measured at the indicated time points. The data are shown as the mean ± SEM, n = 3. ***P < 0.001 vs. NC. c The xenograft weights were compared between different groups. The data are shown as the mean ± SEM, n = 3. ***P < 0.001 vs. NC. d qRT-PCR was performed to detect the expression level of circHECTD1 in the xenografts. The data are shown as the mean ± SEM, n = 3. **P < 0.01, ***P < 0.001 vs. NC. e The expression level of miR-1256 was assessed in the xenografts. The data are shown as the mean ± SEM, n = 3. **P < 0.01, ***P < 0.001 vs. NC. f Representative Ki-67 and USP5 immunostaining of the xenografts