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. 2019 Jan 5;16(4):335–343. doi: 10.1007/s13770-018-0172-4

Fig. 1.

Fig. 1

A Zinc finger nucleases (ZFNs) and B transcription activator-like effector nucleases (TALENs) genome engineering platform. The ZFNs and TALENs are engineered to bind a desired sequence, and then fused to the FokI endonuclease to create targeted double strand breaks