Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 26;10:784. doi: 10.3389/fphar.2019.00784

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Kawiak, Domachowska, Krolicka, Smolarska and Lojkowska

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects of 3-chloroplumbagin on the inhibition of MAP kinase signaling in breast cancer cells. (A) Effects of ChPL on the expression levels of proteins involved in MAP kinase signaling. Protein levels were assessed by Western blot analysis. Densitometric analysis represents protein levels normalized to total ERK1/2 and MEK1/2 levels. (B) Effects of ChPL on the levels of p-ERK 1/2 (Thr202/Tyr204) in MDA-MB-468 and MCF-7 cells. Protein levels were determined with the AlphaScreen assay. (C) Effects of ChPL and AG1478 on the levels of p-ERK 1/2 (Thr202/Tyr204) in MDA-MB-468 and MCF-7 cells. Protein levels were determined with the AlphaScreen assay. Data were analyzed by one-way ANOVA with Tukey’s post hoc tests [p < 0.05 (*), p < 0.01 (**), p < 0.001 (***); n = 3].