FIG 7.

Expression of the identified ISG following in ZIKV-infected ex vivo placenta explants. Tissue explants were prepared from placenta samples from first trimester pregnancy terminations. Tissue explants were infected with ZIKV (MOI, 1; overnight). (A to C) RNA was produced at the indicated time points and analyzed using qRT-PCR with IFN-λ2 (A), IFI6 (B), or ISG20 (C). (D) The graph in shows the infection levels doing the course of the experiment. Shown are data from 3 different donors. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ***, P < 0.0001, two-way ANOVA with Sidak’s multiple-comparison test.