TABLE 1.

Analysis of the CRISPR screen^a

Gene IDb	Gene rank by algorithm
	MAGeCK1	MAGeCK2	RIGER 1	RIGER 2
IFI6	1	1	1	1
ISG20	2	2	2	26
ZCCHC6	3	236	3	85
IFN-λ2	4	3	9	64
HELZ2	5	6	3	85
IFN-λR1	6	4	6	40
EGFR	7	18,134	10,142	17,934
IRF1	8	7	140	76
MAVS	9	127	847	19,704
TRIM25	10	89	228	788
MFSD2A	14	3,966	149	10,188
PITPNB	24	927	647	16,783

^aA comparison of the 2 screen repeats and two different analysis algorithms used RIGER and MAGeCK. Values represent gene ranks assigned by the corresponding algorithm in the different repeats. Highest-ranking genes are sorted relative to the results of MAGeCK applied on the first screen. The gene ranks of the first six candidates are robust across the replicates and the algorithm used.

^bID, identifier.