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. 2019 Sep 30;93(20):e00487-19. doi: 10.1128/JVI.00487-19

FIG 1.

FIG 1

Structure of EBNA1 dimer-dimer on DS34. (A) Duplex DNA corresponding to the entire DS element. Sites 1 to 4 are labeled and shaded in blue. The 3-bp separations between sites 4 and 3 and sites 2 and 1 are colored in purple. Orange shading indicates TRF1 and TRF2 binding sites. (B) Duplex DNA used in crystallization of the complex. The same coloring as in panel A is used. Underlined bases in the TRF sites are those that had discernible electron density in the crystal structure. (C) Crystal structure of EBNA1-DNA complex. The DNA coloring is the same as in panel A. One EBNA1 dimer is colored in shades of green (chain A, darker; chain B, lighter); the other dimer is colored in shades of yellow (chain C, darker; chain D, lighter). (D) The two dimer-dimer/DNA complexes of the asymmetric unit. DimerDimer1 is the focus of the paper. DimerDimer2 is rotated 90° into the plane of the page relatively to DimerDimer1. The protein is green and in cartoon representation; DNA is in stick representation. PGP loops are indicated with arrows.