FIG 3.

The dimer-dimer interface. (A) (Left) N480 from chain B (distal to the dimer-dimer interface) interaction with DNA. (Right) N480 from chain A (green) and chain C (yellow) interaction with DNA at the dimer-dimer interface. (B) (Left) R538 from chain A (green) interaction with DNA. (Right) R538 from chain B (green) lies above the DNA, similar to the structure of Bochkarev et al. (PDB code 1B3T). Protein and DNA are colored as in Fig. 1. (C) (Left) Close-up of the EBNA1 dimer-dimer interface. (Upper right) Close-up of interface between chain A (green) and chain C (yellow). D581 and R491 form a hydrogen bonding network at the dimer-dimer interface. (Lower right) Distal nonpolar interacting region at the dimer-dimer interface.