FIG 2.

ZIKV infection activates the OAS-RNase L pathway. (A) A549 cells were mock infected or infected with ZIKV MR766, ZIKV PR, or SINV at an MOI of 1, and RNA was harvested at the indicated times postinfection and analyzed by using an Agilent bioanalyzer for rRNA degradation. (B) A549 cells (WT or KO) were infected with ZIKV PR or SINV at an MOI of 1, and at 24 hpi RNA was harvested and analyzed by using an Agilent bioanalyzer for rRNA degradation. DKO, MAVS/RNase L double KO. Two different RNase L KO clones were assessed (representative data are shown). The data shown are representative of two to three experiments.